Grf analogs vii

Details Grf analogs vii Grf analogs vii

C - Chemistry, Metallurgy

07

K

167/191, 530/7.1

C07K 14/60 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1312704

GRF ANALOGS VII ABSTRACT OF THE DISCLOSURE The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in animals, including humans, which have resistance to enzymatic degradation in the body, and which have the sequence: Image R44 is a natural amino acid; Q1-Q4 are either H or CaMe, provided however that any or all of the residues between R30 and R44, inclusive, may be deleted, and provided also that at least one of Q1- Q4 is CaMe and/or R8 is Lys or Arg and/or R21 is D-Lys or D-Arg. These peptides as well as their nontoxic salts may also be used diagnostically.

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