Grf analogs with increased biological potency

Details Grf analogs with increased biological potency Grf analogs with increased biological potency

C - Chemistry, Metallurgy

07

K

C07K 14/60 (2006.01) A61K 38/25 (2006.01) A61P 5/00 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2342070

The present invention relates to chimeric fatty body-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone deficiencies. The chimeric fatty body-GRF analogs include a hydrophobic moiety (tail), and can be prepared, either by anchoring at least one hydrophobic tail to the GRF, in the chemical synthesis of GRF. The GRF analogs of the present invention are biodegradable, non-immunogenic and exhibit an improved anabolic potency with a reduced dosage and prolonged activity.

Cette invention, qui a trait à des analogues chimères de GRF-corps gras à activité biologique accrue, concerne également leur utilisation en tant qu'agents anabolisants ainsi que leur utilisation pour le diagnostic et le traitement des carences en hormones de croissance. On peut préparer ces analogues chimères de GRF-corps gras comportant une fraction hydrophobe (queue), soit en accrochant au moins une queue hydrophobe au GRF, soit en remplaçant un ou plusieurs acides aminés par un reste pseudomicellaire lors de la synthèse chimique du GRF. Les analogues de GRF selon cette invention, qui sont biodégradables et non immunogènes, font montre d'une activité anabolisante améliorée et ce, sous un dosage réduit et avec prolongement de leur temps d'action.

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