Grf analogs xi

Details Grf analogs xi Grf analogs xi

C - Chemistry, Metallurgy

07

K

C07K 14/60 (2006.01) A61K 38/25 (2006.01)

Patent

CA 2086676

2086676 9220710 PCTABS00017 The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in animals, including humans and also resist enzymatic degradation in the body. Certain preferred peptides have the formula (SEQ ID NO:16): (B)Xaa1-Ala-Asp-Ala-Ile-Phe-Thr-Xaa8-Ser-Tyr-Arg-Lys-Val-Leu-Xaa15-Xaa16-Leu-_ Ser-Ala-Arg-Lys-Leu-Leu-Xaa24-Xaa25-Ile-Nle-Xaa2 8-Arg-Y wherein Xaa1 is Tyr, D-Tyr, Phe, D-Phe, His or D-His; B is H or N.alpha.Me; Xaa8 is Ala, Aib or Asn; Xaa15 is Gly or Ala; Xaa16 is Ala, Aib or Gln; Xaa24 is Ala, Aib or Gln; Xaa25 is Ala, Aib or Asp; Xaa28 is Ser or Asn; Y is NHR with R being H or lower alkyl; provided that at least one of Xaa8, Xaa16, Xaa24, and Xaa25 is Ala or Aib.

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