C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/00 (2006.01) A01N 43/04 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2389550
The invention provides a novel gene, gridlock, and its encoded protein. gridlock plays a role in vascular development and modeling, and a mutation in gridlock has been associated with an aortic arch disease, coarctation. Thus, gridlock nucleic acid molecules and polypeptides can be used in methods of diagnosing, treating, and preventing gridlock-related diseases and conditions, such as aortic arch diseases.
L'invention concerne un nouveau gène glr (gridlock) et sa protéine codée. Ce gène joue un rôle essentiel dans le développement et la modélisation vasculaire, et une mutation de ce gène a été associée à une maladie de la crosse aortique, la coarctation. Les molécules d'acides nucléiques et les polypeptides glr peuvent ainsi être utilisés dans des méthodes de diagnostic, de traitement et de prévention des maladies et des états pathologiques associés audit gène glr, comme les maladies de la crosse aortique.
Fishman Mark C.
Zhong Tao
Smart & Biggar
The General Hospital Corporation
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