Griseofulvin dosage forms

Details Griseofulvin dosage forms Griseofulvin dosage forms

A - Human Necessities

61

K

167/180

A61K 31/34 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/74 (2006.01) C08G 63/08 (2006.01)

Patent

CA 1046938

GRISEOFULVIN DOSAGE FORMS ABSTRACT OF DISCLOSURE Completely miscible melt mixes of amorphous griseofulvin and certain polyglycolides or lactic acid modified polyglycolides are described which are formed by melting together griseofulvin and the polyglycolide or lactic acid modified polyglycolide, the latter having a molecular weight less than 2000 and glycolic acid content of about 60 to 100 mole per cent. The cooled melt is transparent, glassy and capable of being finely divided. The griseofulvin contained therein, between 30 and 60% by weight, is amorphous and the finely divided melt mixture can be subdivided and incorporated into dosage forms.

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