Griseolic acid derivatives, their preparation and their use

Details Griseolic acid derivatives, their preparation and their use Griseolic acid derivatives, their preparation and their use

C - Chemistry, Metallurgy

07

H

260/229

C07H 19/04 (2006.01) C07H 19/02 (2006.01)

Patent

CA 1267409

ABSTRACT New griseolic acid derivatives have various groups attache to the sugar part in place of the adenine group of griseolic acid itself. These groups are all purine derivatives or ring-opened purine analogs. The compounds are useful as inhibitors of phosphodiesterases. They may be prepared by replacing the adenine moiety of griseolic acid and/or dihydrodesoxy griseolic acid and/or by replacing other substituent groups.

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