Gro genes, proteins, and uses thereof

Details Gro genes, proteins, and uses thereof Gro genes, proteins, and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2092924

2092924 9206196 PCTABS00011 Two novel cytokines which are involved in an inflammatory response (inflammatory cytokines) are disclosed. The inflammatory cytokines have been isolated from activated peripheral blood, preferably monocytes adhered to plastic; or peripheral blood leukocytes induced with calcium ionophore and mezerin. The two cytokines are Gro .beta. and .gamma., and their cDNA and amino acid sequences are disclosed. The expression of the genes in various cells is presented. Assay and diagnostic utilities using the cytokines; recombinant materials and procedures; purification procedures; and monoclonal antibodies to the cytokines are also shown.

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