Group a streptococcus crge protein

Details Group a streptococcus crge protein Group a streptococcus crge protein

C - Chemistry, Metallurgy

12

N

C12N 1/21 (2006.01) A61K 38/16 (2006.01) A61K 39/09 (2006.01) A61K 39/39 (2006.01) C07K 14/315 (2006.01) C07K 19/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/25 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2581966

The invention provides methods of screening utilising the CrgE protein and the Streptococcus pyogenes bacterium expressing crgE. The invention also provides bacteria where the crgR and/or the crgE gene has been knocked out. The invention also provides fusion proteins comprising the polypeptide encoded by Spy1542 (crgE) and pharmaceutical compositions comprising CrgE.

L'invention concerne des méthodes de criblage utilisant la protéine CrgE et la bactérie Streptococcus pyogenes exprimantcrgE. L'invention concerne également des bactéries dans lesquelles le crgR et/ou le gène crgE ont été inactivés. L'invention concerne enfin des protéines de fusion comprenant le polypeptide codé par Spy1542 (crgE) et des compositions pharmaceutiques comprenant CrgE.

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