Group b streptococcal phage lysin

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/55 (2006.01) A61K 38/46 (2006.01) A61P 31/04 (2006.01) C07H 21/04 (2006.01) C12N 9/14 (2006.01) C12N 9/50 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2495295

The present disclosure relates to the identification of the phage lysine from group B streptococci (GBS). The nucleic acid sequence and amino acid sequence of the GBS phage lysine is disclosed. The GBS phage lysine is a unique bifunctional protein comprising a glucosidase and an endopeptidease activity. The endopeptidease present in the GBS phage lysis has a substrate specificity that has not been previously reported. The bifunctional GBS phage lysine is effective against groups A, B, C, E and G streptococci. Also described are methods of using the GBS phage lysine for the prevention and treatment of bacterial infections.

L'invention se rapporte à l'identification de la lysine des phages des streptocoques du groupe B (GBS). Elle concerne la séquence nucléotidique et la séquence d'acides aminés de la lysine phagique des streptocoques du groupe B. La lysine des phages des GBS est une protéine bifonctionnelle comprenant une activité glucosidase et une activité endopeptidase. L'endopeptidase présente dans la lysine des phages des GBS présente une spécificité selon substrat qui n'avait pas été décrite jusqu'ici. Cette lysine bifonctionnelle des phages des GBS est efficace contre les streptocoques des groupes A, B, C, E et G. L'invention concerne également des méthodes d'utilisation de cette lysine des phages des GBS pour la prévention et pour le traitement des infections bactériennes.

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