Growth arrest homeobox gene

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/18 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2183863

A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafter referred to as the "Gax gene" and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation. particularly after balloon angioplasty.

On a découvert un nouveau gène homéoboîte d'arrêt de croissance et on a déterminé la séquence de ses nucléotides, aussi bien chez le rat que chez l'homme. L'expression du nouveau gène homéoboîte inhibe la croissance des cellules des muscles vasculaires lisses. Le gène homéoboîte d'arrêt de la croissance appelé ici "gène Gax" et les protéines correspondantes sont utiles pour l'étude de la prolifération des cellules des muscles lisses vasculaires et pour le traitement de maladies des vaisseaux sanguins causées par une prolifération excessive des cellules des muscles lisses, en particulier après une angioplastie utilisant un ballonnet.

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