Growth arrest of proliferating cells by transglutaminase...

Details Growth arrest of proliferating cells by transglutaminase... Growth arrest of proliferating cells by transglutaminase...

A - Human Necessities

61

K

A61K 31/18 (2006.01) A61K 31/00 (2006.01) A61K 31/17 (2006.01)

Patent

CA 2071550

2071550 9108739 PCTABS00005 Proliferating B cells have a cytosolic Transglutaminase (TGase), which exhibits absolute requirement for Ca++ for its activity. The molecular mass of this TGase is 85 kDa. A method for arresting the lymphocytic cell cycle progression in the G1-phase is described by the use of TGase inhibitors, monodansyl cadaverine (MDC) and 1-(5-aminopentyl)-3-phenylthiourea (PPTU). Reversal of this inhibition allows the lymphocytes to enter the S-phase of normal cell cycle progression. A monocytic cell strain exhibits arrest of cell growth and failure to enter S-phase upon treatment with TGase inhibitor.

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