Growth differentiation factor-8

Details Growth differentiation factor-8 Growth differentiation factor-8

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A01K 67/00 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/495 (2006.01) C07K 16/22 (2006.01) C12N 5/00 (2006.01) C12N 15/12 (2006.01) C12N 15/18 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) G01N 33/00 (2006.01)

Patent

CA 2319703

A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-8 (GDF-8) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals, including humans, with antibodies or antisense directed to GDF-8. The animals so treated are characterized by increased muscle tissue and bone content.

Cette invention concerne un animal transgénique non humain faisant partie d'une espèce aviaire, bovine, ovine et porcine et présentant un transgène dont l'activité entrave la production et/ou l'activité du facteur-8 de différentiation de la croissance (GDF-8) intégré aux chromosomes des cellules germinales dudit animal. L'invention concerne également des techniques d'obtention et des méthodes de traitement de tels animaux, humains y compris, au moyen d'anticorps dirigés contre le facteur-8 ou de séquences antisens dudit facteur. Les animaux traités de cette manière se caractérisent par une masse tissulaire et osseuse accrue.

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