C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A01K 67/00 (2006.01) A23L 1/325 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2382048
A transgenic non-human aquatic organisms, such as piscine, crustacean, mollusks, and the like, having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-8 (GDF-8) chromosomally integrated into the germ cells of the aquatic organism is disclosed. Also disclosed are methods for making such organisms and nucleic acid sequences encoding GDF-8 polypeptides from such aquatic organisms.
La présente invention concerne des organismes aquatiques non-humains transgéniques, tels que des poissons, des crustacés, des mollusques et analogues, possédant un transgène qui est à l'origine de l'interruption de la production et/ou de l'activité du facteur 8 de croissance et différenciation (growth differentiation factor-8/GDF-8) intégré à un chromosome des cellules germinales de l'organisme aquatique. Cette invention concerne également des procédés de production de tels organismes et des séquences d'acide nucléique codant pour des polypeptides GDF-8 provenant de tels organismes aquatiques.
Lee Se-Jin
Mcpherron Alexandra C.
Mbm Intellectual Property Law Llp
The Johns Hopkins University School Of Medicine
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