Growth differentiation factor-9 regulatory sequences and...

Details Growth differentiation factor-9 regulatory sequences and... Growth differentiation factor-9 regulatory sequences and...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 48/00 (2006.01) C07K 14/475 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2324286

Isolated GDF-9 regulatory sequences are disclosed, as well as methods of using the sequences to modulate tissue-specific expression of genes. The GDF-9 regulatory sequences include, for example, enhancer and promoter elements that naturally drive transcription of GDF-9 in specific tissues. The GDF-9 regulatory sequences can be derived from the untranscribed upstream (e.g., first 10 kilobases) and downstream regions, and transcribed, untranslated regions of a GDF-9 gene.

L'invention concerne des séquences isolées régulatrices du facteur 9 de différenciation de croissance (GDF-9), ainsi que des méthodes d'utilisation de ces séquences pour moduler l'expression spécifique à des tissus de gènes. Les séquences régulatrices du GDF-9 comprennent, par exemple, des éléments promoteurs commandant naturellement la transcription du GDF-9 dans des tissus spécifiques. Les séquences régulatrices du GDF-9 peuvent être dérivées de régions en amont non transcrites (par exemple, les 10 premières kilobases) ou de régions en aval non transcrites, et de régions non traduites mais transcrites du gène GDF-9.

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