Growth factor-binding compounds and methods of use

Details Growth factor-binding compounds and methods of use Growth factor-binding compounds and methods of use

A - Human Necessities

61

K

A61K 31/196 (2006.01) A61K 31/245 (2006.01) A61K 31/44 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2553674

Growth factor binding compounds having a plurality of acyclic isophthalic acid groups attached to a non-peptide organic scaffold and pharmaceutical compositions of the same are disclosed. Methods of administering and using the growth factor binding compounds or the growth factor binding compositions are also taught. These novel growth factor binding compounds are useful for treating angiogenesis, excessive cellular proliferation, tumor growth, and a combination thereof as well as inhibiting growth factor binding to cells and phosphorylation.

Cette invention concerne des composés de liaison du facteur de croissance comportant une pluralité de groupes d'acide isophtalique acyclique fixés à un squelette organique non peptidique et concerne également des compositions pharmaceutiques les contenant. Cette invention concerne en outre des méthodes permettant d'administrer et d'utiliser les composés de liaison du facteur de croissance ou des compositions de liaison du facteur de croissance. Ces nouveaux composés de liaison du facteur de croissance servent à traiter l'angiogenèse, la prolifération cellulaire excessive, la croissance tumorale et une combinaison de ces phénomènes et servent également à inhiber la liaison du facteur de croissance à des cellules et la phosphorylation.

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