Growth factor complex comprising an insulin-like growth...

A - Human Necessities – 61 – K

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A61K 38/39 (2006.01) A61K 38/27 (2006.01) A61K 38/30 (2006.01) A61K 38/31 (2006.01) A61P 1/00 (2006.01) A61P 5/00 (2006.01) A61P 9/10 (2006.01) A61P 19/04 (2006.01) A61P 19/10 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2424394

An isolated protein complex is provided which includes a growth factor, growth factor binding protein and vitronectin. Preferably, the isolated protein complex includes an insulin-like growth factor-I, insulin-like growth factor binding protein-3 or insulin-like growth factor binding protein-5 and vitronectin. Also provided are methods of modulating cell proliferation and/or migration by administering said protein complex for the purposes of wound healing, skin repair and tissue replacement therapy. Conversely, by using agents that disrupt growth factor protein complexes formed in vivo, growth factor-driven cell proliferation and/or migration may be suppressed such as for the purposes of treating cancers, psoriasis, atherosclerosis and wounds prone to hypertrophic scarring.

La présente invention concerne un complexe protéique isolé qui comprend un facteur de croissance, une protéine de liaison du facteur de croissance et de la vitronectine. De préférence, le complexe protéique isolé contient un facteur de croissance 1 de type insuline, une protéine 3 de liaison du facteur de croissance de type insuline ou une protéine 5 de liaison du facteur de croissance de type insuline et de la vitronectine. Cette invention concerne également des procédés qui permettent de moduler la prolifération cellulaire et/ou la migration des cellules au moyen de l'administration dudit complexe protéique pour guérir des blessures et pour la thérapie de réparation cutanée et de remplacement tissulaire. Inversement, l'utilisation d'agents qui altèrent les complexes protéiques de facteur de croissance formés in vivo permet de supprimer la prolifération et/ou la migration cellulaire pour traiter des cancers, le psoriasis, l'athérosclérose et des blessures prédisposées à la cicatrisation hypertrophique.

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