Growth factor compositions, preparation and use

Details Growth factor compositions, preparation and use Growth factor compositions, preparation and use

C - Chemistry, Metallurgy

12

P

C12P 21/04 (2006.01) A61K 38/18 (2006.01) C07K 14/485 (2006.01)

Patent

CA 2089143

The invention in growth factor compositions includes: a novel compound which is a separate pure nicked or pure non- nicked species of epidermal growth factor EGF1-48 or its hEGF1-47 or hEGF1-49 congener compound, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition in dosage form comprising an effective amount of the novel compound; and use thereof for treating abnormal cell growth conditions including gastrointestinal/duodenal lesions; and methods of mak- ing the pure hEGF species. This unique therapeutic utility is enhanced by the unexpected and heretofore unappreciated structural stability and resistance of the pure species to enzymatic degradation.

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