A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A61K 31/415 (2006.01) A61K 31/417 (2006.01) A61K 31/70 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 39/395 (2006.01)
Patent
CA 2206527
The use of an agent for controlling vascular permeability within the cervix is disclosed for controlling cervical ripening. To hasten cervical ripening, the agent is one which increases vascular permeability, e.g., vascular endothelial growth factor (VEGF) or platelet-activating factor (PAF). If cervical ripening is to be delayed, the agent is one which reduces vascular permeability, e.g., a VEGF receptor antagonist or antibody or a PAF receptor antagonist or antibody. The agents of the present invention can be used as a means of managing labour.
L'invention porte sur l'utilisation d'un agent influant sur la perméabilité vasculaire pour agir sur la maturation du col de l'utérus. Pour accélérer ladite maturation, l'agent doit renforcer la perméabilité vasculaire; il peut consister par exemple en facteur de croissance endothélial vasculaire (VEGF) ou en facteur d'activation des plaquettes (PAF). Si par contre la maturation du col doit être retardée, l'agent peut être un antagoniste ou un anticorps du récepteur du VEGF ou du récepteur du PAF. Les agents objets de l'invention peuvent servir à diriger le travail.
Ahmed Asif Syed
Ahmed Asif Syed
Marks & Clerk
The University Of Birmingham
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