Growth factor homolog zvegf3

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C07K 14/52 (2006.01) C07K 16/22 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2354325

Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprises an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

Cette invention a trait à des facteurs de croissance polypeptidiques, à des procédés de production de ceux-ci, à des polynucléotides les codant ainsi qu'à des méthodes d'utilisation de ceux-ci. Le polypeptide comporte un segment aminoacide étant, à 90 % au moins, identique aux restes 46-163 de la SEQ ID N·:2 ou aux restes 235-345 de la SEQ ID N·:2. L'invention porte également sur des multimères de ces polypeptides. Il est possible d'utiliser ces polypeptides, ces protéines multimères et ces polynucléotides pour étudier le développement cellulaire et tissulaire et pour réguler celui-ci, comme de les utiliser en tant que composants de milieux de culture cellulaire et en tant qu'agents de diagnostic.

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