Growth factor homolog zvegf4

Details Growth factor homolog zvegf4 Growth factor homolog zvegf4

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2370948

Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70 % identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

L'invention concerne des facteurs de croissance polypeptidiques, des procédés de fabrication correspondants, des polynucléotides les codant, leurs anticorps et des procédés pour les utiliser. Ces polypeptides comprennent un segment d'acides aminés qui est identique pour au moins 70 % aux résidus 52-179 de SEQ ID NO:2 ou aux résidus 258-370 de SEQ ID NO:2. L'invention concerne aussi des multimères de ces polypeptides. Les polypeptides, les protéines multimères et les polynucléotides peuvent être utilisés dans l'étude et la régulation du développement des tissus et des cellules, en tant que composants du milieu de culture des cellules et comme agents diagnostiques.

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