Growth hormone releasing factor analogs

Details Growth hormone releasing factor analogs Growth hormone releasing factor analogs

C - Chemistry, Metallurgy

07

K

167/205, 530/7.1

C07K 14/60 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1254000

RAN 4105/75 Abstract New polypeptides corresponding to growth hormone relea- sing factor in which methionine at position 27 has been re- placed by a leucine or norleucine residue retain full growth hormone releasing activity. In the case of the full length (44-amino acid) polypeptide, the leucine analog has full biological activity in the free acid form, unlike the natural growth releasing factor which requires carboxy terminal amidation for full biological activity. The new compounds are prepared in accordance with conventional methods.

448864

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