Growth hormone secretagogue related receptors and nucleic acids

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/18 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2333857

This invention relates to a new family of receptors, growth hormone secretagogue-related receptors, which exhibit moderate sequence identity to both the growth hormone secretagogue receptor (GHS-R) and the neurotensin receptor (NT-R). These newly identified receptors are expressed in a diverse set of tissues. This invention also relates to nucleic acids encoding these receptors, and to the use of these receptors to identify ligands that modulate growth hormone release or other endocrine functions.

L'invention concerne une nouvelle famille de récepteurs, à savoir les récepteurs en rapport avec un sécrétagogue d'hormone de croissance, qui manifestent une identité de séquence modérée par rapport au récepteur de sécrétagogue d'hormone de croissance (GHS-R) et au récepteur de neurotensine (NT-R). Ces récepteurs nouvellement identifiés sont exprimés dans un ensemble divers de tissus. L'invention concerne aussi les acides nucléiques codant pour ces récepteurs et l'utilisation de ces récepteurs pour identifier les ligands qui modulent la libération de l'hormone de croissance ou d'autres fonctions endocrines.

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