C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/062 (2006.01) A61K 38/05 (2006.01) A61P 19/00 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2362303
What is disclosed are growth hormone secretagogues, and their uses, of formula (I) wherein R1 is C6H5CH2OCH2-, C6H5(CH2)3- or indol-3-ylmethyl; Y is pyrrolidin-1-yl, 4-C1-C6 alkylpiperidin-1-yl or NR2R2; R2 are each independently a C1 to C6 alkyl; R3 is 2-napthyl or phenyl para-substituted by W; W is H, F, CF3, C1-C6 alkoxy or phenyl; and R4 is H or CH3, or a pharmaceutically acceptable salt or solvate thereof.
La présente invention concerne des sécrétagogues d'hormones de croissance, et les utilisations de ceux-ci, représentés par la formule (I). Dans cette formule R1 est C¿6?H¿5?CH¿2?OCH¿2?-, C¿6?H¿5?(CH¿2?)¿3?- ou indol-3-ylméthyle; Y est pyrrolidine-1-yl, 4-C¿1?-C¿6? alkylpiperidine-1-yl ou NR2R2; R2 sont chacuns indépendamment alkyle de C¿1? en C¿6?; R3 est 2-napthyle ou phényle para-substitué par W; W est H, F, CF¿3?, C¿1?-C¿6? alcoxy ou phényle; and R4 est H ou CH¿3?, ou un sel pharmaceutiquement acceptable ou soluble de ces composés.
Dodge Jeffrey Alan
Lugar Charles Willis III
Eli Lilly & Company
Gowling Lafleur Henderson Llp
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