Grp78 as a predictor of responsiveness to therapeutic agents

Details Grp78 as a predictor of responsiveness to therapeutic agents Grp78 as a predictor of responsiveness to therapeutic agents

G - Physics

01

N

G01N 33/574 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2665387

The present application provides methods for detecting, diagnosing, monitoring, predicting responsiveness to therapeutic agents and staging cancer. The present application provides methods and compositions useful for suppression of GRP78 expression or activity in cancer cells to overcome resistance of certain therapeutic agents. The present application also provides methods for predicting whether a subject with cancer is at risk for developing resistance to certain therapeutic agents.

L'invention concerne des procédés pour détecter, diagnostiquer, surveiller, prévoir une sensibilité à des agents thérapeutiques et évaluer le stade d'un cancer. L'invention concerne des procédés et des compositions utiles pour la suppression d'une expression ou d'une activité GRP78 dans des cellules cancéreuses pour surmonter la résistance à certains agents thérapeutiques. L'invention concerne également des procédés pour prévoir si un sujet atteint d'un cancer risque de développer une résistance à certains agents thérapeutiques.

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