Gsk-3 inhibitors

Details Gsk-3 inhibitors Gsk-3 inhibitors

A - Human Necessities

61

K

A61K 31/17 (2006.01) A61K 31/36 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 25/00 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) C07D 317/66 (2006.01)

Patent

CA 2616451

The invention relates to urea derivatives of formula (I) as inhibitors of glycogen synthase kinase 3~, GSK-3, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which GSK-3 is involved, such as Alzheimer's disease or non-insulin dependent diabetes mellitus.

L'invention concerne des dérivés d'urée représentés par la formule (I), utilisés comme inhibiteurs de la glycogène synthase kinase 3ß, GSK-3, des procédés permettant de préparer ces composés, des compositions pharmaceutiques contenant ces composés, et l'utilisation de ces composés pour le traitement et/ou la prévention d'une maladie faisant intervenir la GSK 3, telle que la maladie d'Alzheimer ou le diabète non insulinodépendant.

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