A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/497 (2006.01) A61P 19/10 (2006.01)
Patent
CA 2644751
The present invention relates to a new use of a compound of the formula (I) wherein R1 is NH2, piperazin-1-yl, 4-methylpiperazin-1-yl, 4-methyl-1,4-diazepan-1-yl or 4-ethylpiperazin-1-yl; R2 is hydrogen, fluoro, CH3, CH2CH3, OCH3, CF3 or OCF3; R3 is hydrogen, CH3 or fluoro; as a free base or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the prevention and/or treatment of bone-related disorders, osteoporosis and increasing bone formation, bone mineral density. The present invention further relates to a method of prevention and/or treatment of these disorders.
La présente invention concerne une nouvelle utilisation, en tant que base libre, d'un composé de formule (I), dans laquelle R1 est NH2, pipérazin-1-yle, 4-méthylpipérazin-1-yle, 4-méthyl-1,4-diazépan-1-yle ou 4-éthylpipérazin-1-yle; R2 est hydrogène, fluoro, CH3, CH2CH3, OCH3, CF3 ou OCF3; R3 est hydrogène, CH3 ou fluoro; ou un sel pharmaceutiquement acceptable dudit composé. Le composé est utilisé dans la fabrication d'un médicament destiné à la prévention et/ou au traitement de maladies osseuses, de l'ostéoporose, ou à accélérer la formation osseuse ou la densité minérale des os. L'invention concerne en outre une méthode de prévention et/ou de traitement desdites maladies.
Berg Anna-Lena
Bhat Ratan
Astrazeneca Ab
Mccarthy Tetrault Llp
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