C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 453/02 (2006.01) A61K 31/415 (2006.01) A61K 31/4184 (2006.01) A61K 31/439 (2006.01) A61K 31/4427 (2006.01) A61K 31/4523 (2006.01) A61K 31/47 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 23/00 (2006.01) A61P 29/00 (2006.01) C07D 235/30 (2006.01) C07D 401/02 (2006.01) C07D 403/02 (2006.01) C07D 405/02 (2006.01) C07D 405/06 (2006.01) C07D 409/00 (2006.01) C07D 409/06 (2006.01) C07D 413/00 (2006.01)
Patent
CA 2487122
Novel guanidine compounds having the formula (I) in which Rl, R2 and R4 are as defined, are effective as sodium channel blockers in neuronal mammalian cells and as anesthetics and/or analgesics, particularly local spinal and/or epidural anesthetics, for alleviation of neuropathic pain, for providing a neuroprotective effect, and for producing anti~convulsant effects.
L'invention porte sur de nouveaux composés de guanidine de formule (I) dans laquelle R¿1?, R¿2? et R¿4? sont tels que définis dans le descriptif et qui sont efficaces comme agents bloquants des canaux de sodium dans des cellules mammaliennes neuronales et comme anesthésiques et/ou analgésiques, notamment comme anesthésiques rachidiens locaux et/ou périduraux, et sont utilisés pour soulager la douleur névropathique, générer un effet neuroprotecteur et produire des effets anticonvulsifs.
Drasner Kenneth
Weber Kevin T.
Mediquest Therapeutics Inc.
Moffat & Co.
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