Guanidine derivatives

Details Guanidine derivatives Guanidine derivatives

C - Chemistry, Metallurgy

07

D

260/314, 260/310

C07D 233/66 (2006.01) C07D 209/48 (2006.01) C07D 233/88 (2006.01) C07D 277/48 (2006.01)

Patent

CA 1097658

ABSTRACT The invention relates to guanidine derivatives which are histamine H-2 antagonists and which inhibit the secretion of gastric acid, to methods for their manufacture and to pharmaceutical compositions containing them. The guanidine derivatives are of the general formula I:- Image I in which X is S or NH, Y is O, S, SO, CH2, a direct bond or a vinylene radical, m is 0 to 4 and n is 1 to 4, R1 is hydrogen, halogen or alkyl, R2 is hydrogen, alkyl, alkanoyl or aroyl, A is a 3,4-di- oxocyclobuten-1,2-diyl radical or C=Z in which Z is O, S, NCN, NNO2, CHNO2, C(CN)2, NCOR3, NCO2R3, NSO2R3 or NR4 in which R3 is a lkyl or aryl and R4 is hydrogen or alkyl, B is alkoxy or alkylthio or NR5R6 in which R5 and R6 are independently hydrogen, alkyl, alkenyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, alkyl- aminoalkyl or dialkylaminoalkyl; and the salts thereof.

301263

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