C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/315
C07D 231/38 (2006.01) C07D 231/16 (2006.01) C07D 231/40 (2006.01) C07D 263/48 (2006.01) C07D 277/48 (2006.01)
Patent
CA 1282782
Abstract A guanidine derivative of the formula I:- Image I in which R1, R2, R3, R4, ring X and D are a variety of radicals defined in the specification and A is a 3-8C alkylene chain which is substituted by a hydroxy radical and into which is optionally inserted, as part of the backbone of the chain, one or two groups selected from oxygen and sulphur atoms and NH and 1-6C N-alkyl radicals; and the pharmaceutically-acceptable acid additions salts thereof. Pharmaceutical compositions and methods of manufacture are also described. The compound of the formula I is a histamine H-2 antagonist and is therefore useful in ulcer therapy.
472742
Kirkland Karin M.
Mant Derrick M.
Barlow Charles Brian
Ici Americas Inc.
Imperial Chemical Industries Plc
Kirkland Karin M.
Mant Derrick M.
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