Guanidine derivatives as inhibitors of na+/h+ exchange in cells

C - Chemistry – Metallurgy – 07 – D

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C07D 207/337 (2006.01) A61K 31/155 (2006.01) A61K 31/33 (2006.01) C07C 279/22 (2006.01) C07D 207/327 (2006.01) C07D 207/335 (2006.01) C07D 207/34 (2006.01) C07D 213/58 (2006.01) C07D 231/14 (2006.01) C07D 257/04 (2006.01) C07D 277/30 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01) C07D 333/38 (2006.01) C07D 401/02 (2006.01) C07D 401/04 (2006.01) C07D 401/10 (2006.01) C07D 413/04 (2006.01) C07D 498/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2163004

Guanidine derivatives of formula (I), wherein Y is N or C-R1 (in which R1 is hydrogen, lower alkyl, hydroxy, protected hydroxy, etc.), R2 is hy- drogen, aryl which may have one suitable sub- stituent, aryloxy, etc., R3 is hydrogen, lower alkoxy, hydroxy, protected hydroxy, etc., Z is N or C-R4 (in which R4 is hydrogen, carboxy, protected carboxy, nitro, halogen, hydroxy(lower)alkyl, etc.), and W is N or C-R12 (in which R12 is hydrogen, lower alkoxy, nitro, hydroxy or protected hydroxy), and pharmaceutically acceptable salts thereof which are useful as a medicament.

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