Guanidinium transport reagents and conjugates

Details Guanidinium transport reagents and conjugates Guanidinium transport reagents and conjugates

C - Chemistry, Metallurgy

08

G

C08G 69/48 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01) A61P 35/00 (2006.01) C07H 15/00 (2006.01) C07K 7/00 (2006.01) C07K 7/64 (2006.01) C07K 14/00 (2006.01) C07K 17/08 (2006.01) C08G 71/04 (2006.01) C08G 73/02 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2469336

Transport reagents and conjugates of therapeutic agents linked to transport reagents are described. In particular, the transport reagents have a plurality of guanidinium moieties that are either contiguous or spaced along a backbone, but are sufficiently removed from the backbone via tethers, to allow their interaction with a cell or tissue surface, leading to uptake of the therapeutic agent.

L'invention concerne des réactifs de transport et des conjugués d'agents thérapeutiques liés auxdits réactifs. En particulier, ces réactifs présentent une pluralité de fractions guanidinium qui sont soit contiguës soit espacées le long d'un squelette, mais sont suffisamment séparées du squelette, par l'intermédiaire de thioéthers, pour permettre leur interaction avec une cellule ou une surface de tissu, entraînant l'absorption de l'agent thérapeutique.

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