Guanidinyl- or amidinyl-substituted methylamino heterocyclic...

C - Chemistry – Metallurgy – 07 – D

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D 401/12 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07D 207/08 (2006.01) C07D 207/09 (2006.01) C07D 211/60 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07K 5/062 (2006.01) C07K 5/065 (2006.01) C07K 5/068 (2006.01) C07K 5/072 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2122646

Abstract METHYLAMINO HETEROCYCLIC THROMBIN INHIBITORS Guanidinyl- or amidinyl-substituted heterocyclic thrombin inhibitors are provided which have the structure Image wherein n is 0, 1 or 2; R1 is -A-R2, -CO-A-R2 or -SO2-A-R2; wherein R2 is guanidine, amidine or amino, and A is an alkyl, alkenyl or alkynyl chain of 2 to 6 carbons; or R1 is -(CH2)p-A'-R2 or -(CH2)p-CO-A'R2' where p is 0, 1 or 2, R2' is amidine and A' is an azacycloalkyl or azaheteroalkyl ring of 4 to 8 atoms, optionally substituted by alkyl, CO or halo; R1 is -(CH2)p-A"-R2", -(CH2)p-CO-A"-R2", or -(CH2)p-SO2-A" -R2", wherein R2"is guanidine, amidine or aminomethyl, and A" is aryl or cycloalkyl; and R3, R4, R5 and R6 are as defined herein.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Guanidinyl- or amidinyl-substituted methylamino heterocyclic... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Guanidinyl- or amidinyl-substituted methylamino heterocyclic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Guanidinyl- or amidinyl-substituted methylamino heterocyclic... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1418955

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.