Guanosine triphosphate (gtp)-binding protein-coupled...

Details Guanosine triphosphate (gtp)-binding protein-coupled... Guanosine triphosphate (gtp)-binding protein-coupled...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2429214

By searching for the homology of the amino acid sequences of known G protein- coupled receptor proteins with GenBank, a novel human GPCR gene BG37 is obtained. cDNA containing ORF of this gene is cloned and thus the base sequence is determined. Moreover, novel GPCR BG37 genes originating in mouse and rat are isolated. Use of this novel GPCR makes it possible to screen a ligand, to screen a compound inhibiting the binding to a ligand, and to screen a candidate compound for a drug capable of controlling the signal transduction from a BG37 receptor.

L'invention concerne un nouveau gène GPCR humain <= BG37 >=, obtenu par détermination de l'homologie entre des séquences d'acides aminés de protéines du récepteur couplé aux protéines G (GPCR) connues et une banque de gènes. Le cadre de lecture ouvert (ORF), contenant l'ADNc, de ce gène est cloné, ce qui permet de déterminer la séquence de bases. De plus, de nouveaux gènes GPCR <= BG37 >= issus de la souris ou du rat sont isolés. L'utilisation de ce nouveau GPCR permet de sélectionner un ligant, un composé inhibant la liaison à un ligand et un composé candidat pour un médicament capable de contrôler la transduction de signal depuis un récepteur <= BG37 >=.

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