C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/83 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/42 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2340596
The present invention provides an eukaryotic expression vector comprising the Guanylate Binding Protein 1 (GBP-1) gene or parts thereof. The introduction of said vector comprising said gene or parts thereof in sense or antinsense orientation into cells can be used to induce phenotypical changes of said cells and can, thus, be used for modulation of cell differentiation. Additionally, the present invention provides said vector for the treatment of cancer, sarcoma, lymphoma, hemangioma, artherosclerosis or restenosis, but also the treatment of inflammatory diseases like chronic ulcerative diseases, psoriasis, insect bites, freezing or burning injuries, wound healing or Morbus Crohn. Furthermore, the present invention provides, inter alia, a method for determination of the stage of cellular differentiation by using GBP-1 gene expression as a marker.
L'invention porte sur un vecteur eucariote d'expression comportant le gène de la protéine 1 de fixation du guanylate (GPB-1) ou l'une de ses parties. L'introduction dudit vecteur comportant ledit gène ou de l'une de ses parties selon l'orientation sens ou antisens dans des cellules peut servir à induire des changements phénotypiques desdites cellules, et donc, à moduler la différenciation cellulaire. L'invention porte également sur l'utilisation dudit vecteur pour le traitement des cancers, sarcomes, lymphomes, hémangiomes, resténoses et de l'arthérosclérose, mais également celui de maladies inflammatoires telles que les ulcères chroniques, le psoriasis, les piqûres d'insectes, les engelures et brûlures, les cicatrices, ou la maladie de Crohn. L'invention porte en outre notamment sur une méthode de détermination du stade de différentiation cellulaire utilisant l'expression du gène (GPB-1) comme marqueur.
Cornali Emmanuelle
Sturzl Michael
Bavarian Nordic Research Institute A/s
Prof.dr.rer.nat.michael Sturzl
Shapiro Cohen
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