Guanylate-cyclase c ligand, administered via the airways,...

Details Guanylate-cyclase c ligand, administered via the airways,... Guanylate-cyclase c ligand, administered via the airways,...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61M 15/00 (2006.01) A61P 11/00 (2006.01) C07K 7/08 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2464511

The invention relates to the use of a guanylate cyclase C activated peptide for the treatment of respiratory airway problems and problems associated with ventilation disorder and/or mucous secretion disorders via the airways, in addition to a medicament which is fed via the airways. The invention also relates to an inhalation device which contains the medicament and a method for diagnosing the illnesses associated with inhalation disorders and mucous secretion disorders in the airways, by detecting a guanylate cyclase C activated peptide. The peptides which are used are guanylin, uroguanylin and lymphoguanylin or a heat resistant enterotoxin.

Utilisation d'un peptide qui active la guanylate-cyclase C pour le traitement de maladies des voies respiratoires et de maladies associées à des troubles de la ventilation et / ou à des troubles de la sécrétion des muqueuses, par les voies aériennes, ainsi que médicament qui est administré par les voies aériennes. La présente invention concerne en outre un dispositif d'inhalation qui contient le médicament et une méthode de diagnostic de maladies associées à des troubles de la ventilation et à des troubles de la muqueuse dans les voies respiratoires, par détection d'un peptide activant la guanylate-cyclase C. Les peptides utilisés sont la guanyline, l'uroguanyline et la lymphoguanyline ou une entérotoxine thermorésistante.

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