A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/167 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01) A61P 37/06 (2006.01) C07C 281/18 (2006.01)
Patent
CA 2271693
There is disclosed a method for treating diseases and disorders involving T cell activation and HIV-infection, using the p38 mitogen activated protein kinase (MAPK) signaling pathway as a target for intervention. There is further disclosed a use for guanylhydrazone-substituted compounds to treat diseases and disorders related to T cell activation and HIV-infection.
L'invention se réfère à un procédé destiné au traitement de maladies et de troubles impliquant l'activation des cellules T et une infection au VIH, dans lequel on utilise la voie de signalisation de la protéine kinase activée par mitogène (MAPK) p38 comme cible d'intervention. L'invention se réfère également à une utilisation de composés guanylhydrazone-substitués dans le traitement de maladies et de troubles liés à l'activation des cellules T et à une infection au VIH.
Bukrinsky Michael
Cohen Pamela
Schmidtmayerova Helena
Tracey Kevin
Cytokine Pharmasciences Inc.
Smart & Biggar
The Picower Institute For Medical Research
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