Guanylyl cyclase c qrt-pcr

Details Guanylyl cyclase c qrt-pcr Guanylyl cyclase c qrt-pcr

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2760050

Methods, kits, compositions and systems for detecting the level of GCC encoding mRNA present in a sample using quantitative (q) RT-PCR are disclosed. The methods, kits, compositions and systems may be used to detect metastasis in patients diagnosed with primary colorectal, gastric or esophageal cancer, to predict the risk of occurrence of relapse in patients diagnosed with primary colorectal, gastric or esophageal cancer, and to diagnose Barrett's esophagus.

L'invention porte sur des procédés, des kits, des compositions et des systèmes pour détecter le niveau d'ARNm codant pour la GCC présent dans un échantillon à l'aide de RT-PCR quantitative (q). Les procédés, kits, compositions et systèmes peuvent être utilisés pour détecter une métastase chez des patients pour lesquels on a diagnostiqué un cancer colorectal, gastrique ou sophagien primaire, pour prédire le risque d'apparition d'une rechute chez des patients pour lesquels on a diagnostiqué un cancer colorectal, gastrique ou sophagien primaire, et pour diagnostiquer un sophage de Barrett.

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