Gyrase inhibitors

Details Gyrase inhibitors Gyrase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/416 (2006.01) A61K 31/426 (2006.01) A61P 31/04 (2006.01) C07D 417/14 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2537860

Compounds comprising an indazolyl group and a thiazolyl group, preferably 7- substituted 3-(thiazol-2-yl)-1H-indazole compounds in which the indazolyl group and a thiazolyl group are each independently optionally substituted, are useful for the treatment or prophylaxis of bacterial infections in mammals. The compounds are believed to function by inhibiting gyrase B.

L'invention concerne des composés contenant un groupe indazolyle et un groupe thiazolyle, de préférence, des composés de 3-(thiazol-2-yl)-1H-indazole substitués en 7, dans lesquels le groupe indazolyle et le groupe thiazolyle sont respectivement substitués de manière indépendante et facultative. Ces composés sont utilisés dans le traitement ou la prophylaxie d'infections bactériennes chez des mammaliens et ils sont susceptibles de fonctionner par inhibition de la gyrase B.

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