Gyrase inhibitors and uses thereof

Details Gyrase inhibitors and uses thereof Gyrase inhibitors and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/4155 (2006.01) A61K 31/421 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61P 31/04 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2397686

The present invention relates to compounds of formula (I) where Ring A is a thiazole, oxazole, imidazole or pyrazole and the substituents are as described in the specification, and pharmaceutically aceptable salts thereof. The compounds inhibit bacterial gyrase activity and therefore are useful for treating bacterial infections in mammals.

Cette invention a trait à des composés correspondant à la formule (I) ainsi qu'à leurs sels acceptables du point de vue pharmaceutique. Dans cette formule, A représente un thiazole, un oxazole, un imidazole ou un pyrazole. Les substituants sont tels que définis dans la description. Ces composés, qui inhibent l'activité de la gyrase bactérienne, se révèlent efficaces s'agissant de traiter des infections bactériennes chez les mammifères.

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