Gyrase inhibitors and uses thereof

Details Gyrase inhibitors and uses thereof Gyrase inhibitors and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 235/30 (2006.01) A61K 31/33 (2006.01) A61K 31/4184 (2006.01) A61K 31/423 (2006.01) A61K 31/437 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61K 45/06 (2006.01) A61P 31/04 (2006.01) C07D 263/58 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 471/04 (2006.01) C07D 4

Patent

CA 2433197

The present invention relates to compounds of the formula (I): or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to methods for decreasing bacterial quantity in a biological sample.

L'invention concerne des composés de formule I: ou un dérivé ou un promédicament acceptable sur le plan pharmaceutique de ceux-ci. Les composés sont utiles comme inhibiteurs de l'activité de la gyrase bactérienne. L'invention concerne également des méthodes de traitement d'infections bactériennes chez des mammifères, ainsi que des méthodes permettant de réduire la quantité de bactéries dans un échantillon biologique.

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