H2 antagonist-alginate-antacid combinations

Details H2 antagonist-alginate-antacid combinations H2 antagonist-alginate-antacid combinations

A - Human Necessities

61

K

A61K 31/425 (2006.01) A61K 31/715 (2006.01) A61K 31/80 (2006.01) A61K 33/00 (2006.01) A61K 33/08 (2006.01) A61K 33/10 (2006.01)

Patent

CA 2166731

This invention relates to pharmaceutical composition for use in the treatment and relief of indigestion, sour stomach, heartburn and other gastrointestinal disorders in mammals, including humans, by administering compositions comprising: (i) an amount effective in the relief of gastrointestinal or esophagus disorders of an H2 antagonist selected from a compound of formula (I) and its pharmaceutically acceptable salts, hydrates, stereoisomersor polymorphs and (ii) an amount effective in relief of gastrointestinal or esophagus disorders of at least one of the alginates and (iii) an amount effective in relief of gastrointestinal distress of an antacid wherein the antacid provides a buffering effect and generates carbon dioxide to aerate the alginate.

Cette invention concerne des compositions pharmaceutiques utilisables dans le traitement et le soulagement des indigestions, des aigreurs d'estomac, des brûlures d'estomac et des autres troubles gastro-intestinaux chez les mammifères, y compris l'homme. Ce traitement comprend l'administration de compositions comportant: (i) une quantité, efficace pour le soulagement des troubles gastro-intestinaux ou de l'oesophage, d'un antagoniste H2 sélectionné parmi un composé de la formule (I) et ses sels, hydrates, stéréo-isomères ou composés polymorphes pharmaceutiquement acceptables et (ii) une quantité, efficace pour le soulagement des troubles gastro-intestinaux ou de l'oesophage, d'au moins un alginate et (iii) une quantité, efficace pour le soulagement des embarras gastro-intestinaux, d'un antiacide procurant un effet régulateur et générant du dioxyde de carbone pour aérer l'alginate.

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