H2 antagonist-gastrointestinal motility agent combinations

Details H2 antagonist-gastrointestinal motility agent combinations H2 antagonist-gastrointestinal motility agent combinations

A - Human Necessities

61

K

A61K 38/47 (2006.01) A61K 31/425 (2006.01) A61K 31/445 (2006.01) A61K 31/80 (2006.01)

Patent

CA 2166730

This invention relates to phar- maceutical compositions for use in the prevention, treatment and relief of indi- gestion, sour stomach, heartburn, gas- troesophageal reflux, dyspepsia, consti- pation, over-indulgence and other gas- trointestinal disorders in mammals, in- cluding humans, by administering compositions comprising: (i) an amount effective in the relief of gastrointestinal or esophagus disordors of an H2 antagonist selected from a compound of formula (I) and pharmaceutically acceptable salts, hydrates, stereoisomers or polymorphs thereof, and (ii) an amount effective in the relief of gastrointestinal or esophagus disorders and in the promotion of gastric emptying of a gastrointestinal motility agent such as cisapride, and optionally (iii) an amount effective in the reliof of flatulence of simethicone or alpha-D-galactosidase.

L'invention concerne des préparations pharmaceutiques destinées à la prévention, au traitement et au soulagement des indigestions, de l'hyperacidité gastrique, des brûlures épigastriques, des reflux gastro-oesophagiens, des dyspepsies, des constipations, des excès et autres troubles gastro-intestinaux des mammifères, y compris de l'homme, par administration de composés associant: (i) une quantité d'anti-H2 suffisante pour soulager les désordres gastro-intestinaux ou oesophagiens, l'anti-H2 étant sélectionné dans la famille de composés dont la formulation est (I) ainsi que de leurs dérivés sous forme de sels, d'hydrates, de stéréoisomères ou de polymorphes de qualité pharmaceutiques; (ii) un agent facilitant la motilité gastro-intestinale tel que le cisapride, en quantité suffisante pour soulager les troubles gastro-intestinaux ou oesophagiens et accélérer le transit gastro-duodénal; et le cas échéant (iii) du siméthicone ou de l'alpha-D-galactosidase en quantité suffisante pour soulager les flatulences.

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