C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 39/42 (2006.01) A61P 31/16 (2006.01) C07K 14/11 (2006.01) C07K 16/10 (2006.01) C12N 15/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/563 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2687147
The invention provides monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes of avian influenza virus ("AIV"). The monoclonal antibodies and related binding proteins are useful for the detection of H5 subtypes of AIV, including the pathogenic H5N1 subtypes. Virus may be detected in formalin preserved, paraffin embeded specimens as well as frozen specimens and biological fluids. Accordingly, the invention provides means for the diagnosis and surveillance of dangerous viral infections.
L'invention concerne des anticorps monoclonaux et des protéines de liaison associées qui se lient spécifiquement à la glycoprotéine d'enveloppe des sous-types H5 du virus de la grippe aviaire (<=AIV >=). Les anticorps monoclonaux et les protéines de liaison associées sont utiles pour la détection des sous-types H5 de l'AIV, notamment des sous-types pathogènes H5N1. Les virus peuvent être détectés dans des spécimens enrobés de paraffine, conservés dans le formol, ainsi que dans des spécimens congelés et des fluides biologiques. Par conséquent, l'invention fournit des moyens permettant le diagnostic et la surveillance d'infections virales dangereuses.
Fang He
Fern Ho Yuen
Sing Jimmy Kwang Hwei
Yun Du Qing
Osler Hoskin & Harcourt Llp
Temasek Life Sciences Laboratory Limited
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