C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/102 (2006.01) C07K 14/285 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2399480
This invention relates to recombinant bacterial outer membrane proteins comprising one or more LB1(f) peptides from surface-exposed loop 3 of MOMP P5 of non-typeable H. influenzae. Polynucleotides encoding these recombinant proteins are also covered. The invention also relates to a method of isolating the recombinant proteins and a vaccine composition for use in the treatment of Haemophilus influenzae infection.
La présente invention concerne des protéines de membrane externe bactériennes recombinées comprenant un ou plusieurs peptides LB1(f) de la boucle 3 de MOMP P5 exposée à la surface du H. influenzae non typable. L'invention concerne également les polynucléotides codant pour ces protéines recombinées ainsi qu'un procédé permettant d'isoler ces protéines recombinées et une composition de vaccin destiné au traitement des infections à Haemophilus influenzae.
Bakaletz Lauren
Berthet Francois-Xavier Jacques
Denoel Philippe
Poolman Jan
Thonnard Joelle
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Smithkline Beecham Biologicals S.a.
The Ohio State University Research Foundation
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