Hairless immunodeficient mouse model

A - Human Necessities – 01 – K

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A01K 67/027 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2718419

The invention is directed to a hairless, immunodeficient mouse that is homozygous recessive for a hairless (Hr hr) allele and both B-cell deficient and T-cell deficient. The B-cell and T-cell deficiency is attributed to a homozygous recessive scid allele (Prkdc scid) a homozygous recessive beige allele (Lyst bg), or a mutated Rag allele. These mice offer an advantage over nude mouse models used in cancer research because they can be maintained as homozygous breeding pairs and they have greater immune deficits, which permit better growth of xenogenic tumor lines, and rapid assessment of cutaneous and subcutaneous tumors and tissue grafts.

L'invention porte sur une souris immunodéficiente glabre qui est récessive homozygote pour un allèle glabre (Hrhr) et à la fois déficiente en lymphocytes B et déficiente en lymphocytes T. La déficience en lymphocytes B et en lymphocytes T est attribuée à un allèle SCID récessif homozygote (Prkdcscid), un allèle beige récessif homozygote (Lystbg) ou un allèle Rag muté. Ces souris offrent un avantage par rapport aux modèles de souris nudes utilisés dans la recherche pour le cancer en raison du fait qu'elles peuvent être maintenues sous forme de paires d'élevages homozygotes et quelles ont des déficits immunitaires plus importants, ce qui permet une meilleure croissance de lignées tumorales xénogènes, et une évaluation rapide de tumeurs cutanées et sous-cutanées et de greffes tissulaires.

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