(halo-benzo carbonyl)heterobicyclic p38 kinase inhibiting...

Details (halo-benzo carbonyl)heterobicyclic p38 kinase inhibiting... (halo-benzo carbonyl)heterobicyclic p38 kinase inhibiting...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61K 31/5377 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) C07D 471/02 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2488567

Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I)are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

L'invention concerne des composés représentés par la formule chimique (I) ou des sels pharmaceutiquement acceptables de ces composés, lesquels sont des inhibiteurs de p38 et conviennent au traitement des inflammations, notamment le traitement de la polyarthrite rhumatoïde, de la spondylarthrite ankylosante, de l'ostéoarthrite, de l'arthrite goutteuse et d'autres maladies arthritiques ; des inflammations articulatoires, de l'eczéma, du psoriasis ou d'autres maladies cutanées inflammatoires, notamment les coups de soleil ; des maladies ophtalmiques inflammatoires, notamment la conjonctivite ; de la fièvre, de la douleur et d'autres maladies associées aux inflammations.

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