C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/56 (2006.01) A61K 31/423 (2006.01) A61P 17/06 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2539306
The application is directed to haloalkyl-substituted compounds of Formula (I), wherein R1, R1a, R2, R3, R4~ and E are as defined in the claims. The compounds are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. Pharmaceutical compositions comprising these compounds and their use are also disclosed.
La présente invention concerne des composés substitués par haloalkyle représentés par la formule (I) dans laquelle R4 représente haloalkyle et, R?1¿, R?1a¿, R?2¿, R?3¿, R?4¿ et E sont tels que définis dans les revendications. Ces composés sont des inhibiteurs de cystéine protéases, en particulier, des cathépsines B, K, L, F, et S et qui conviennent par conséquent pour le traitement de maladie induite par ces protéases. Cette invention concerne aussi des compositions pharmaceutiques comprenant ces composés et des processus de préparation de ses compositions.
Axys Pharmaceuticals Inc.
Sim & Mcburney
Virobay Inc.
LandOfFree
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