Haloalkyl containing compounds as cysteine protease inhibitors

Details Haloalkyl containing compounds as cysteine protease inhibitors Haloalkyl containing compounds as cysteine protease inhibitors

C - Chemistry, Metallurgy

07

C

C07C 255/46 (2006.01) A61K 31/277 (2006.01) A61P 17/06 (2006.01) A61P 37/00 (2006.01) C07C 317/48 (2006.01) C07C 323/60 (2006.01) C07D 213/32 (2006.01) C07D 241/12 (2006.01) C07D 309/14 (2006.01) C07D 333/20 (2006.01) C07D 335/02 (2006.01)

Patent

CA 2521811

The application is directed to haloalkyl-substituted compounds of formula (I) wherein R7 represents haloalkyl; and R1, R2, R3, R4, R5, R6 and R8 are as defined in the claims. The compounds are inhibitors of cysteine proteases, in particular cathepsins B, K, L, F and S and are therefore useful in treating diseases mediated by these proteases. Pharmaceutical compositions containing these compounds and their use are also disclosed.

La présente invention concerne des composés qui sont des inhibiteurs de cystéine protéases, en particulier, des cathépsines B, K, L, F, et S et qui conviennent par conséquent pour le traitement de maladie induite par ses protéases. Cette invention concerne aussi des compositions pharmaceutiques comprenant ces composés et des processus de préparation de ses compositions.

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