C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/00 (2006.01) A61K 31/52 (2006.01) A61P 3/00 (2006.01) A61P 9/00 (2006.01) C07D 473/32 (2006.01)
Patent
CA 2595182
Provided herein are Aminopurine Compounds having the following structure: (I) wherein R1 , R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia- reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
L'invention porte sur des composés d'aminopurine de formule (I) dans laquelle: R1, R2 et R3 sont tels que définis dans la description et pouvant traiter ou prévenir, le cancer, les maladies cardio-vasculaires, les maladies rénales, les états auto-immunes, les états inflammatoires, la dégénérescence maculaire, l'ischemie-reperfusion, la douleur et les syndromes associés, l'amaigrissement morbide, troubles liés à l'amiante, l'hypertension pulmonaire et les syndromes associés, ou tout état pouvant être traité ou prévenu par inhibition du mécanisme de la voie JNK, le traitement ou la prévention se faisant par administration d'une dose efficace d'un composé d'aminopurine à un patient le nécessitant.
Albers Ronald
Ayala Leticia
Clareen Steven S.
Delgado Mederos Maria M.
Hegde Sayee
Osler Hoskin & Harcourt Llp
Pharmacopeia Drug Discovery Inc.
Signal Pharmaceuticals Llc
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