A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/52 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2684999
Provided herein are Aminopurine Compounds having the following structure (I), wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine. Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
L'invention porte sur des composés d'aminopurine de formule (I), dans laquelle R1, R2 et R3 sont tels que définis dans le présent document, compositions comprenant une quantité efficace d'un composé d'aminopurine. Le composé et les procédés de traitement ou de prévention du cancer, de la maladie cardiovasculaire, de la maladie rénale, de l'état auto-immune, de l'état inflammatoire, de la dégénérescence maculaire, de l'ischémie-reperfusion, de la douleur et des syndromes associés, de l'amaigrissement morbide, des troubles liés à l'amiante, de l'hypertension pulmonaire ou de tout état pouvant être traité ou prévenu par inhibition du mécanisme de la voie JNK comprenant l'administration d'une dose efficace d'un composé d'aminopurine à un patient le nécessitant.
Albers Ronald J.
Ayala Leticia
Clareen Steven S.
Delgado Mederos Maria Mercedes
Hegde Sayee G.
Osler Hoskin & Harcourt Llp
Signal Pharmaceuticals Llc
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